肺癌是起源于支气管黏膜上皮或肺泡上皮的恶性肿瘤,又称支气管肺癌或原发性肺癌,是全球死亡率排名第一的癌症,其发病率及死亡率仍在逐年上升,是对人类健康威胁最大的癌症。据中国国家癌症中心2022年发布的数据统计显示,肺癌在男性与女性群体中的发病率分别第1位及第2位,死亡率均居首位。因此,针对肺癌的基础研究不仅有助于阐明其病因和发病机理,而且对于肺癌的诊断和防治具有重要的临床意义。体外培养的正常肺细胞和肺癌细胞作为重要的研究模型,越来越广泛地应用于生物医学研究,成为相关领域不可缺少的实验材料、研究对象和研究工具。近日,国家模式与特色实验细胞资源库和国家生物医学实验细胞库基于广大用户的共性需求,共同整理并推出一批肺癌相关的实验细胞主题资源。
细胞名称 (首字母排序) | 疾病类型 | 基因序列改变信息 | 资源保藏机构 | 资源标识符 | 资源链接 |
A-427 | 人肺腺癌 | CTNNB1基因突变:p.Thr41Ala (c.121A>G) KRAS突变:p.Gly12Asp (c.35G>A) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP579 | https://www.cellbank.org.cn/search-detail.php?id=783 |
A549 | 人肺腺癌 | KRAS基因突变:p.Gly12Ser (c.34G>A) STK11基因突变:p.Gln37Ter (c.109C>T) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP503 | https://www.cellbank.org.cn/search-detail.php?id=518 |
国家生物医学实验细胞库 | CSTR:16607.09.1101HUM-PUMC000002 | http://www.cellresource.cn/fdetail.aspx?id=3870 | |||
Calu-1 | 人肺鳞癌 | 基因缺失:TP53 KARS基因突变:p.Gly12Cys (c.34G>T) TERT启动子突变:c.1-124C>T (c.228C>T) | 国家生物医学实验细胞库 | CSTR:16607.09.1101HUM-PUMC000935 | http://www.cellresource.cn/fdetail.aspx?id=7908 |
Calu-3 | 人肺腺癌 | TP53基因突变:p.Met237Ile (c.711G>T) | 国家生物医学实验细胞库 | CSTR:16607.09.1101HUM-PUMC000329 | http://www.cellresource.cn/fdetail.aspx?id=3900 |
Calu-6 | 人肺退行性癌 | KRAS基因突变:p.Gln61Lys (c.180_181TC>CA) TP53基因突变:p.Arg196Ter (c.586C>T) | 国家生物医学实验细胞库 | CSTR:16607.09.1101HUM-PUMC000813 | http://www.cellresource.cn/fdetail.aspx?id=4590 |
ChaGo-K-1 | 人肺支气管癌 | ARID1A剪接受体突变:c.1921-2A>G ARID1A基因突变:p.His684Asp (c.2050C>G) RB1基因突变:p.Glu837Lys (c.2509G>A) TP53基因突变:p.Cys275Phe (c.824G>T) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP5070 | https://www.cellbank.org.cn/search-detail.php?id=762 |
DMS 153 | 人小细胞肺癌 | TP53基因突变:p.Thr155Pro (c.463A>C) | 国家生物医学实验细胞库 | CSTR:16607.09.1101HUM-PUMC000397 | http://www.cellresource.cn/fdetail.aspx?id=4200 |
DMS 114 | 人小细胞肺癌 | PARD3B突变:外显子Ex2-14可能缺失 TP53突变:p.Arg213Ter (c.637C>T) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP5079 | https://www.cellbank.org.cn/search-detail.php?id=777 |
DMS 53 | 人小细胞肺癌 | TP53突变:p.Glu56Ter (c.166G>T) TP53突变:p.Ser241Phe (c.722C>T) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP5083 | https://www.cellbank.org.cn/search-detail.php?id=780 |
HCC827 | 人肺腺癌 | EGFR突变:p.Glu746_Ala750del (c.2236_2250del15) TP53突变:p.Val218del (c.646_648GTG) (c.652_654delGTG) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP538 | https://www.cellbank.org.cn/search-detail.php?id=625 |
国家生物医学实验细胞库 | CSTR:16607.09.1101HUM-PUMC000478 | http://www.cellresource.cn/fdetail.aspx?id=4272 | |||
NCI-H1299 | 人肺大细胞癌 | 基因缺失:TP53 NRAS突变:p.Gln61Lys (c.181C>A) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP589 | https://www.cellbank.org.cn/search-detail.php?id=660 |
国家生物医学实验细胞库 | CSTR:16607.09.1101HUM-PUMC000469 | http://www.cellresource.cn/fdetail.aspx?id=4264 | |||
NCI-H1395 | 人肺腺癌 | ATM突变:p.Thr2666Ala (c.7996A>G) BRAF突变:p.Gly469Ala (c.1406G>C) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP539 | https://www.cellbank.org.cn/search-detail.php?id=631 |
NCI-H1437 | 人肺腺癌 | TP53突变:p.Arg267Pro (c.800G>C) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP591 | https://www.cellbank.org.cn/search-detail.php?id=620 |
NCI-H146 | 人小细胞肺癌 | KMT2D突变:p.Glu2911Ter (c.8731G>T) KMT2D突变:p.Glu4588Ter (c.13762C>T) RB1突变:p.Gln850Ter (c.2548C>T) TP53突变:p.Pro318Leufs*21 (c.953_971del19) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP5075 | https://www.cellbank.org.cn/search-detail.php?id=765 |
NCI-H157 | 人肺腺癌 (胸水) | CDKN2A突变:p.His83Tyr (c.247C>T) (p.Ala97Val, c.290C>T) KRAS突变:p.Gly12Arg (c.34G>C) TP53突变:p.Leu35fs*8 (c.102_103insT) (c.103_104insT) TP53突变:p.Glu298Ter (c.892G>T) | 国家生物医学实验细胞库 | CSTR:16607.09.1101HUM-PUMC000113 | http://www.cellresource.cn/fdetail.aspx?id=3966 |
NCI-H1568 | 人肺腺癌 | ATM突变:p.Gly506Phe (c.1516_1517GG>TT) TP53突变:p.His179Arg (c.536A>G) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP5072 | https://www.cellbank.org.cn/search-detail.php?id=764 |
NCI-H1650 | 人肺支气管癌 | EGFR突变:p.Glu746_Ala750del (c.2235_2249del15) TP53突变:c.673-2A>G (IVS6-2A>G) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP592 | https://www.cellbank.org.cn/search-detail.php?id=285 |
国家生物医学实验细胞库 | CSTR:16607.09.1101HUM-PUMC000251 | http://www.cellresource.cn/fdetail.aspx?id=4073 | |||
NCI-H1703 | 人肺鳞癌 | CDKN2A突变:p.Asp84Val (c.251A>T) TP53突变:c.919+1G>T (IVS8+1G>T) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP593 | https://www.cellbank.org.cn/search-detail.php?id=726 |
国家生物医学实验细胞库 | CSTR:16607.09.1101HUM-PUMC000353 | http://www.cellresource.cn/fdetail.aspx?id=4162 | |||
NCI-H1734 | 人肺腺癌 | ATM突变:p.Gln65Pro (c.194A>C) KRAS突变:p.Gly13Cys (c.37G>T) RB1突变:p.Ser127Ile (c.380G>T) TP53突变:p.Arg273Leu (c.818G>T) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP594 | https://www.cellbank.org.cn/search-detail.php?id=659 |
NCI-H1944 | 人肺腺癌 | ATR突变:p.Arg2363Ter (c.7087C>T) KRAS突变:p.Gly13Asp (c.38G>A) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP596 | https://www.cellbank.org.cn/search-detail.php?id=671 |
NCI-H196 | 人小细胞肺癌 | 未知 | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP5088 | https://www.cellbank.org.cn/search-detail.php?id=789 |
NCI-H1975 | 人肺腺癌 | EGFR突变:p.Thr790Met (c.2369C>T) EGFR突变:p.Leu858Arg (c.2573T>G) PIK3CA突变:p.Gly118Asp (c.353G>A) TP53突变:p.Arg273His (c.818G>A) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP597 | https://www.cellbank.org.cn/search-detail.php?id=623 |
国家生物医学实验细胞库 | CSTR:16607.09.1101HUM-PUMC000252 | http://www.cellresource.cn/fdetail.aspx?id=4074 | |||
NCI-H209 | 人小细胞肺癌 | RB1突变:p.Cys706Phe (c.2117G>T) TP53突变:c.673-2A>T (IVS6-2A>T) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP5089 | https://www.cellbank.org.cn/search-detail.php?id=791 |
国家生物医学实验细胞库 | CSTR:16607.09.1101HUM-PUMC000045 | http://www.cellresource.cn/fdetail.aspx?id=3912 | |||
NCI-H2009 | 人肺腺癌 | B2M突变:p.Met1Val (c.1A>G) B2M突变:p.Gln28Ter (c.82C>T) KRAS突变:p.Gly12Ala (c.35G>C) TERT突变:c.1-124C>T (c.228C>T) (C228T) TP53突变:p.Arg273Leu (c.818G>T) | 国家生物医学实验细胞库 | CSTR:16607.09.1101HUM-PUMC000383 | http://www.cellresource.cn/fdetail.aspx?id=4187 |
NCI-H2087 | 人肺腺癌 | ATM突变:p.Glu848Gln (c.2542G>C) BRAF突变:p.Leu597Val (c.1789C>G) MYC突变:p.Glu54Lys (c.160G>A) NRAS突变:p.Gln61Lys (c.181C>A) TP53突变:p.Val157Phe (c.469G>T) | 国家生物医学实验细胞库 | CSTR:16607.09.1101HUM-PUMC000253 | http://www.cellresource.cn/fdetail.aspx?id=4075 |
NCI-H2126 | 人肺大细胞癌 | SMARCA4突变:p.Trp764Arg (c.2290T>A) TP53突变:p.Glu62Ter (c.184G>T) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP599 | https://www.cellbank.org.cn/search-detail.php?id=675 |
NCI-H2170 | 人肺鳞癌 | RHOA突变:p.Gly17Val (c.50G>T) TP53突变:p.Arg158Gly (c.472C>G) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP5098 | https://www.cellbank.org.cn/search-detail.php?id=820 |
国家生物医学实验细胞库 | CSTR:16607.09.1101HUM-PUMC000354 | http://www.cellresource.cn/fdetail.aspx?id=4163 | |||
NCI-H2227 | 人小细胞肺癌 | TP53突变:c.783-2A>C | 国家生物医学实验细胞库 | CSTR:16607.09.1101HUM-PUMC000254 | http://www.cellresource.cn/fdetail.aspx?id=4076 |
NCI-H2228 | 人肺腺癌 | 基因融合:EML4-ALK 基因融合:ALK-PTPN3 TP53突变:p.Gln331Ter (c.991C>T) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP5001 | https://www.cellbank.org.cn/search-detail.php?id=661 |
NCI-H23 | 人肺腺癌 | ATM突变:p.Gln1919Pro (c.5756A>C) KRAS突变:p.Gly12Cys (c.34G>T) STK11突变:p.Trp332Ter (c.996G>A) TP53突变:p.Met246Ile (c.738G>C) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP581 | https://www.cellbank.org.cn/search-detail.php?id=679 |
NCI-H2347 | 人肺腺癌 | B2M突变:p.Gln28Ter (c.82C>T) KRAS突变:p.Leu19Phe (c.57G>T) NRAS突变:p.Gln61Arg (c.182A>G) TP53突变:p.Thr125Thr (c.375G>A) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP5002 | https://www.cellbank.org.cn/search-detail.php?id=651 |
NCI-H226 | 人肺鳞癌 | 基因缺失:CDKN2A | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP5073 | https://www.cellbank.org.cn/search-detail.php?id=761 |
国家生物医学实验细胞库 | CSTR:16607.09.1101HUM-PUMC000936 | http://www.cellresource.cn/fdetail.aspx?id=7909 | |||
NCI-H292 | 人肺粘液上皮样癌 | 基因融合:CRTC1-MAML2, MECT1-MAML2 NF2突变:p.Pro496Thrfs*8 (c.1484_1485insA) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP582 | https://www.cellbank.org.cn/search-detail.php?id=618 |
国家生物医学实验细胞库 | CSTR:16607.09.1101HUM-PUMC000233 | http://www.cellresource.cn/fdetail.aspx?id=4057 | |||
NCI-H358 | 人肺支气管癌 | 基因缺失:TP53 KRAS突变:p.Gly12Cys (c.34G>T) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP583 | https://www.cellbank.org.cn/search-detail.php?id=680 |
国家生物医学实验细胞库 | CSTR:16607.09.1101HUM-PUMC000470 | http://www.cellresource.cn/fdetail.aspx?id=4265 | |||
NCI-H446 | 人小细胞肺癌 | 基因融合:PVT1-LY6H TP53突变:p.Gly154Val (c.461G>T) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP5086 | https://www.cellbank.org.cn/search-detail.php?id=788 |
国家生物医学实验细胞库 | CSTR:16607.09.1101HUM-PUMC000991 | http://www.cellresource.cn/fdetail.aspx?id=7964 | |||
NCI-H460 | 人大细胞肺癌 | KRAS突变:p.Gln61His (c.183A>T) PIK3CA突变:p.Glu545Lys (c.1633G>A) STK11突变:p.Gln37Ter (c.109C>T) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP584 | https://www.cellbank.org.cn/search-detail.php?id=632 |
国家生物医学实验细胞库 | CSTR:16607.09.1101HUM-PUMC000355 | http://www.cellresource.cn/fdetail.aspx?id=4164 | |||
NCI-H524 | 人小细胞肺癌 | ATM突变:p.Arg337Cys (c.1009C>T) RB1突变:p.Ser576Ter (c.1727C>G) TP53突变:p.Thr155Asn (c.464C>A) | 国家生物医学实验细胞库 | CSTR:16607.09.1101HUM-PUMC000356 | http://www.cellresource.cn/fdetail.aspx?id=4588 |
NCI-H526 | 人小细胞肺癌 | TP53突变:c.97-1G>C (IVS3-1G>C) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP5087 | https://www.cellbank.org.cn/search-detail.php?id=787 |
NCI-H596 | 人肺鳞癌 | PIK3CA突变:p.Glu545Lys (c.1633G>A) RB1突变:p.Ser182fs*3 (c.541_542insT) TP53突变:p.Gly245Cys (c.733G>T) | 国家生物医学实验细胞库 | CSTR:16607.09.1101HUM-PUMC000257 | http://www.cellresource.cn/fdetail.aspx?id=4078 |
NCI-H661 | 人大细胞肺癌 | CDKN2A突变:c.457+1G>T LASP1突变:p.Glu48Ter (c.142G>T) TP53突变:p.Arg158Leu (c.473G>T) TP53突变:p.Ser215Ile (c.644G>T) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP5071 | https://www.cellbank.org.cn/search-detail.php?id=763 |
国家生物医学实验细胞库 | CSTR:16607.09.1101HUM-PUMC000357 | http://www.cellresource.cn/fdetail.aspx?id=4165 | |||
NCI-H69 | 人小细胞肺癌 | PIK3CA突变:p.Gly106_Arg108del (c.317_325delGGCAACCGT) RB1突变:p.Glu748Ter (c.2242G>T) TP53突变:p.Glu171Ter (c.511G>T) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP5077 | https://www.cellbank.org.cn/search-detail.php?id=776 |
国家生物医学实验细胞库 | CSTR:16607.09.1101HUM-PUMC000358 | http://www.cellresource.cn/fdetail.aspx?id=4166 | |||
NCI-H82 | 人小细胞肺癌 | 基因融合:PVT1-MYH7 TP53突变:p.Thr125Thr (c.375G>T) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP5078 | https://www.cellbank.org.cn/search-detail.php?id=775 |
NCI-H838 | 人肺腺癌 | ARID1A突变:p.Pro1876Serfs*22 (c.5625_5632del) ARID1A突变:(p.CPP1657fs) (c.5621_5628delGCCCACCA TP53突变:p.Glu62Ter (c.184G>T) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP588 | https://www.cellbank.org.cn/search-detail.php?id=619 |
PC-9 | 人肺腺癌 | EGFR突变:p.Glu746_Ala750del (c.2235_2249del15) TP53突变:p.Arg248Gln (c.743G>A) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP5085 | https://www.cellbank.org.cn/search-detail.php?id=781 |
SK-LU-1 | 人肺腺癌 | ARID1A突变:p.Asn1253fs*16 (c.3753delC) KRAS突变:p.Gly12Asp (c.35G>A) TP53突变:p.His193Arg (c.578A>G) | 国家生物医学实验细胞库 | CSTR:16607.09.1101HUM-PUMC000237 | http://www.cellresource.cn/fdetail.aspx?id=4059 |
SK-MES-1 | 人肺鳞癌 | TP53突变:p.Glu298Ter (c.892G>T) | 国家模式与特色实验细胞资源库 | https://www.cellbank.org.cn/search-detail.php?id=633 | |
国家生物医学实验细胞库 | CSTR:16607.09.1101HUM-PUMC000262 | http://www.cellresource.cn/fdetail.aspx?id=4080 | |||
SHP-77 | 人小细胞肺癌 | ABL1突变:p.Val1128Glu (c.3383T>A) KRAS突变:p.Gly12Val (c.35G>T) RAC1突变:p.Tyr32Cys (c.95A>G) TP53突变:p.Cys176Trp (c.528C>G) | 国家模式与特色实验细胞资源库 | CSTR:19375.09.3101HUMSCSP5074 | https://www.cellbank.org.cn/search-detail.php?id=766 |
备注(符号缩写):del:deletion,缺失;ins:insert,插入;fs:frameshift,移码。
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